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People with Heart Disease* and Those Who Have Had a Stroke Are at High Risk of Developing Complications from Influenza (the Flu) People with heart disease and those who have had a stroke are at high risk for developing serious complications from the flu. Among adults hospitalized with the flu during the 2015-2016 influenza season, heart disease was among the most commonly-occurring chronic conditions; 41% of adults hospitalized with the flu during the 2015-2016 flu season had heart disease. Studies have shown that influenza is associated with an increase of heart attacks and stroke.